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Mechanistically, GLP-1R activation appears to downregulate TNF- production via 1-adrenergic, -opioid, and -opioid receptor pathways (Wong et al., 2024)
Given his results, while I might try just high dose serine first, adding NAC, nicotinamide riboside, glycine and carnitine also makes sense, as Mardinoglus research suggests
This suggests that Samuel cannot reduce GSSG back to GSH as effectively as normal
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